I've been thinking a lot about friendships tailing off and, heh, how to adapt that into a television series.
The protagonist is a bloke in his late 30s or early 40s. In each episode, something happens in his life that reminds him of a friend he once had, and the bulk of every episode is a flashback story. It's friendship presented through a nostalgic prism.
Idea: A team must infiltrate the mind of a blind man to extract information, navigating a world created by someone without a visual frame of reference.