The very first thing said in the movie is, "Man, this girl's trying to fuck up my dick." It's delivered by a CGI joint (FOR REAL) named Slow Burn, voiced by Mystikal (FOR REAL).
At one point, Snoop is leading a contest with several of the students in which they have to blow the most interesting thing with marijuana smoke. A girl inhales from the joint WITH HER ASS and then blows out brown smoke … NOT DONE YET … that Andy Milonakis shotguns.