Is "Bed Intruder Song" eligible for Grammys? It was played on terrestrial radio, sold as a single on iTunes, and charted on Billboard's Hot 100. NARAS may resent the Gregory Brothers, however.
Justin Bieber's "Never Say Never" (The Karate Kid) and Muse's "Neutral Star Collision" (Twilight: Eclipse) are both eligible for a "Best Original Song" Oscar. As AMPAS is desperate to attract younger viewers, and freakin' Three 6 Mafia won an Oscar, I can see nominations for both and a win for one.
The "Best Original Score" category is even more intriguing.
Hans Zimmer is a lock for Inception, and he could face:
Mastodon (Jonah Hex)
Radiohead producer Nigel Godrich (Scott Pilgrim vs. the World)
Trent Reznor (The Social Network)
Daft Punk (Tron: Legacy)